Microneedles, that is, 3D micromechanical structures with microscale cross-sectional dimensions, have been introduced as an alternative to hypodermic needles for minimally inasive drug delivery and blood extraction. In particular, microneedles can be used for the delivery of tansdermal biomolecules such as proteins, vaccines, DNA, antibodies, or genes.
Acutally, various types of hollow microneedles have been fabricated using subtractive micromanufacturing methods such as photolithography, deep reactive ion etching, and deep X-ray lithography of LIGA(Lithographie, Galvanoformung, and Abformung), which is based on the inherently planar geometries of 2D substrates. However, the maximum height of these microneedles is only several hundred micrometers due to limitations of subtractive projection lithography. This height limitation makes penetration of the skin barrier and precise intradermal drug delivery difficult; hence, an ultrahighaspect-ratio(UHAR) microneedle is required to overcome these limitations.
INCYTO Microneedle have been developed to release the limitation and it would be a new innovative paradigm shift for the benefits of humanity.
INCYTO Microneedle is using a technique of drawing lithography in which structures are drawn out of a thermoset polymer in liquid form and then cured. This form is then electroplated to fabricate hollow ultrahigh-aspect-ratio needles for minimally invasive and lower pain drug delivery.
INCYTO Microneedle realized competitive mass production process with stable control of the length of needle by altering the drawing rate and the time of lithography.
It is suitable for more comfortable Insulin Pump and Glucose Monitoring, and it also is applicable to EHD
(Electrohydrodynamic) printing as an electro-spray nozzle.